منابع مشابه
Agrin Isoforms with Distinct Amino Termini
The proteoglycan agrin is required for postsynaptic differentiation at the skeletal neuromuscular junction, but is also associated with basal laminae in numerous other tissues, and with the surfaces of some neurons. Little is known about its roles at sites other than the neuromuscular junction, or about how its expression and subcellular localization are regulated in any tissue. Here we demonst...
متن کاملAgrin Isoforms with Distinct Amino Termini: Differential Expression, Localization, and Function
The proteoglycan agrin is required for postsynaptic differentiation at the skeletal neuromuscular junction, but is also associated with basal laminae in numerous other tissues, and with the surfaces of some neurons. Little is known about its roles at sites other than the neuromuscular junction, or about how its expression and subcellular localization are regulated in any tissue. Here we demonst...
متن کاملAlternative 5' exons and differential splicing regulate expression of protein 4.1R isoforms with distinct N-termini.
Among the alternative pre-mRNA splicing events that characterize protein 4.1R gene expression, one involving exon 2' plays a critical role in regulating translation initiation and N-terminal protein structure. Exon 2' encompasses translation initiation site AUG1 and is located between alternative splice acceptor sites at the 5' end of exon 2; its inclusion or exclusion from mature 4.1R mRNA reg...
متن کاملAgrin isoforms and their role in synaptogenesis.
Agrin is thought to mediate the motor neuron-induced aggregation of synaptic proteins on the surface of muscle fibers at neuromuscular junctions. Recent experiments provide direct evidence in support of this hypothesis, reveal the nature of agrin immunoreactivity at sites other than neuromuscular junctions, and have resulted in findings that are consistent with the possibility that agrin plays ...
متن کاملThe Distinct N-termini of Two Human Hcs Isoforms Influence Biotin Acceptor Substrate Recognition
THE DISTINCT N-TERMINI OF TWO HUMAN HCS ISOFORMS INFLUENCE BIOTIN ACCEPTOR SUBSTRATE RECOGNITION Maria Ingaramo and Dorothy Beckett From the Department of Chemistry and Biochemistry, Center for Biological Structure and Organization, University of Maryland, College Park, MD 20742 Running title: Interaction of HCS isoforms with acceptor protein substrate *Address correspondence to: Dorothy Becket...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2000
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.151.1.41